Three-year-old Lytrell Hume and eight-year-old Terrence Hume have been final seen heading north-east on Cohn Avenue, Carlisle about 7.50am.
Lytrell is described as roughly 80cm tall, of slim construct and with curly golden hair.
He was final seen carrying a blue shirt and brown shorts.
Terrence is described as roughly 130cm tall, of slim construct with quick darkish hair.
He was final seen carrying a blue shirt and darkish blue shorts, carrying a leopard print blanket.
Anybody who sees the boys is requested to stay with them and name police instantly on 131 444.