The proprietor of a property on Canterbury Highway in Blackburn allegedly got here house about 10pm on August 3 to seek out each room had been ransacked.
Jewelry and 50 designer purses had been stolen.
It is believed the property had been stolen a while between midday and 10pm on August 3.
Police have launched images and a video of the purses within the hope somebody recognises them.
Anybody with details about the housebreaking is urged to contact police.
The theft occurred lower than two months after $50,000 value of designer purses had been stolen from a house in the identical suburb on June 15.
Police discovered these purses at a girl's house the next month and had been in a position to return them to the proprietor.