Emergency companies have been known as to the crash on the intersection of Williamstown and Beacon roads in Port Melbourne simply after 1.10pm.
The bike rider, who's but to be formally recognized, died on the scene.
The male driver of the automobile was not injured.
The precise circumstances surrounding the collision are but to be decided.
Drivers are suggested to keep away from the world.
Anybody who witnessed the collision, with dashcam footage or additional info is urged to name Crime Stoppers on 1800 333 000 or submit a confidential report at www.crimestoppersvic.com.au.